Hi, sorry I know this has been subject of a thread before but thew information there didn't work for me and it was an oldish thread anyway so i thought i'd start a new one...
I've just bought Neverwinter Nights 2 and when i try to open the toolset, it crashes to the desktop. These are the details Vista gives me:

Description:
Stopped working

Problem signature:
Problem Event Name: CLR20r3
Problem Signature 01: nwn2toolsetlauncher.exe
Problem Signature 02: 1.0.22.1588
Problem Signature 03: 49a74d8f
Problem Signature 04: NWN2Toolset
Problem Signature 05: 1.0.1588.0
Problem Signature 06: 49a74e27
Problem Signature 07: 3da4
Problem Signature 08: 1b
Problem Signature 09: System.IO.FileNotFoundException
OS Version: 6.0.6001.2.1.0.768.3
Locale ID: 5129

Can anyone help? Thanks!

Do you have DirectX 10 installed?

I was just experiencing the same problem. I have DirectX 10, so I just tried installing DirectX 9.0c and this fixed my problem.